Arsenic Ingested Early in Life Is More Readily Absorbed: Mechanistic Insights from Gut Microbiota, Gut Metabolites, and Intestinal Morphology and Functions

Journal： Advanced Materials ｜ IF:11.357

Time：2025-06-24

Early-life arsenic exposure results in significantly higher absorption than in adulthood. This study links the effect to intestinal morphological differences, rather than microbiota or metabolite changes, highlighting a key mechanism driving heightened vulnerability in young individuals.

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Deciphering the photoactive species-directed antibacterial mechanism of bismuth oxychloride with modulated nanoscale thickness

Journal： Advanced Materials ｜ IF:8.7

Time：2025-06-24

Human African trypanosomiasis (HAT), a deadly parasitic disease in sub-Saharan Africa, may involve the brain much earlier than previously thought. Transcriptomic profiling suggests that host immune and metabolic pathways linked to central nervous system function are activated in early infection, redefining the timeline of neurological involvement in sleeping sickness.

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Development of functional anti-Gn nanobodies specific for SFTSV based on next-generation sequencing and proteomics

Journal： Advanced Materials ｜ IF:6.993

Time：2025-06-24

Severe fever with thrombocytopenia syndrome virus (SFTSV) poses a growing threat to public health. Using next-generation sequencing and phage display, researchers developed functional nanobodies targeting the viral Gn glycoprotein, demonstrating high affinity and strong neutralization potential, with implications for therapeutic antibody design and rapid diagnostic tool development against SFTSV.

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Weighted gene co-expression network analysis and whole genome sequencing identify potential lung cancer biomarkers

Journal： Advanced Materials ｜ IF: 32.1

Time：2025-07-18

By leveraging integrated whole-exome sequencing and comprehensive transcriptomic profiling in lung adenocarcinoma patients, this study reveals critical genomic alterations, immune gene expression changes, and pathway dysregulations, identifying robust biomarkers and therapeutic targets that may enhance diagnostic precision and support the development of personalized treatment strategies for non-small cell lung cancer.

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NME4 suppresses NFκB2-CCL5 axis, restricting CD8+ T cell tumour infiltration in oesophageal squamous cell carcinoma

Journal： Advanced Materials ｜ IF:4.7

Time：2025-07-18

By leveraging advanced single-cell RNA sequencing technology, this study provides a comprehensive analysis of the tumor ecosystem in esophageal squamous cell carcinoma, revealing distinct malignant and immune cell populations, transcriptional heterogeneity, signaling pathways, and cell-cell interactions that uncover novel biomarkers and therapeutic targets for guiding precision oncology and immunotherapeutic intervention strategies.

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