Let's take a look at our Proximity-based Labeling (PL for short) technology!

Let's take a look at our Proximity-based Labeling (PL for short) technology!

For scientific researchers studying molecular biology, when they obtain an interesting gene/protein and want to conduct in - depth functional verification, the study of protein - protein interactions is an essential part. Protein - protein and protein - nucleic acid interactions are widespread in various life processes and play important regulatory roles. Developing methods for large - scale analysis of interactions between biomolecules is of great significance for exploring biological functions and disease intervention. Although traditional biochemical research methods such as pulldown, Co - IP, and yeast two - hybrid are widely used to uncover potential protein - protein interactions, they all have their own drawbacks and limitations.

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2025

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Xianlian Jiedu Decoction alleviates colorectal cancer by regulating metabolic profiles, intestinal microbiota and metabolites

Xianlian Jiedu Decoction alleviates colorectal cancer by regulating metabolic profiles, intestinal microbiota and metabolites

"With government support, publishing is not a problem." Traditional Chinese medicine (TCM) research has always been a hot topic. The typical research pattern is component identification → network pharmacology analysis → molecular docking analysis → experimental validation. These routines may have become tiresome. Today, I would like to share a different research strategy in TCM: a combination of non-targeted TCM analysis + gut microbiota + metabolomics. This approach is novel, highly reproducible, and you too can publish such a paper using this strategy.

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2025

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Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC

Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC

At the forefront of modern medical research, scientists are using techniques like single-cell RNA sequencing and bulk transcriptome analysis to probe the mysteries of cancer. It’s akin to holding a high-powered microscope to listen to cancer’s “inner monologue,” one cell at a time. Today, let’s explore a new study that unveils the hidden role of a crucial metabolic pathway in head and neck squamous cell carcinoma (HNSCC)—the serine-glycine-one-carbon (SGOC) metabolism. What’s more, the study introduces a magical 4-SGOC gene prognostic signature, like a “map of the future” for clinicians. Let’s dive into this scientific adventure!

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2025

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06

Fully assembled spliceosome pre activation structure of brewing yeast

Fully assembled spliceosome pre activation structure of brewing yeast

RNA splicing is one of the important processes in regulating gene expression in eukaryotes. In the 1970s, scientists first discovered the discontinuity of eukaryotic genes, indicating that after genetic information is transferred from DNA to RNA, it needs to undergo "cutting" and "splicing" of effective genetic information. This splicing of effective genetic information and the removal of "invalid" genetic information is called RNA splicing. RNA splicing is widely present in eukaryotes. With the evolution of species, the number of genes containing introns increases, and the frequency of RNA splicing also increases accordingly, making it possible for one gene to encode multiple proteins.

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2025

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Sequencing reveals gene switch controlling wing pattern of armyworm

Sequencing reveals gene switch controlling wing pattern of armyworm

An important goal of studying evolution is to identify the genetic changes behind the emergence of a new morphological structure in organisms. According to the official website of the University of Cambridge in the UK, scientists have found through genetic sequencing analysis of various Amazon armyworms that the gene switches that control different stripes and spots on their wings are independent, and different armyworms have these gene switches, like a gene "paintbrush box" that can produce new patterns through cross species mating.

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2025

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New study reveals 241 genes associated with brain dysfunction

New study reveals 241 genes associated with brain dysfunction

Researchers from the Geisinger Health System in Pennsylvania, USA, compiled 241 genes related to brain dysfunction and discovered 17 new gene mutations associated with brain developmental disorders, including autism, epilepsy, schizophrenia, and bipolar disorder. The related research results were published on January 28, 2016 in the journal JAMA Psychiatry.

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